NRIP3 (nuclear receptor interacting protein 3), also known as C11orf14 or NY-SAR-105, is a 241 amino acid protein that is encoded by a gene which maps to human chromosome 11. With approximately 135 million base pairs and 1,400 genes, chromosome 11 comprises approximately 4% of human genomic DNA and is considered a gene and disease association dense chromosome. The chromosome 11 encoded Atm gene is important for regulation of cell cycle arrest and apoptosis following double strand DNA breaks.