Mouse Monoclonal Antibody to HDAC4
货号：
30871
别名：
HD4; AHO3; BDMR; HDACA; HA6116; HDAC-4; HDAC-A
应用：
IHC,FCM
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
P56524
规格：
目录价
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Description |
|---|
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. |
References |
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| 1.Cancer Res. 2013 Feb 15;73(4):1386-99. 2.Am J Hum Genet. 2010 Aug 13;87(2):219-28. |
Specification |
|
|---|---|
| Aliases | HD4; AHO3; BDMR; HDACA; HA6116; HDAC-4; HDAC-A |
| Entrez GeneID | 9759 |
| Swissprot | P56524 |
| clone | 5E4A5 |
| WB Predicted band size | 119kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human HDAC4 (AA: 456-592) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
Application |
|
|---|---|
| IHC | 1/200 - 1/1000 |
| FCM | 1/200 - 1/400 |
| ELISA | 1/10000 |
Product Image
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Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);
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Flow cytometric analysis of HeLa cells using HDAC4 mouse mAb (green) and negative control (red).
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Immunohistochemical analysis of paraffin-embedded human endometrial cancer tissues using HDAC4 mouse mAb with DAB staining.
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